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Dextrose prolotherapy is a nonsurgical technique involving the injection of dextrose into an injured area to stimulate healing.  Most commonly, the dextrose is injected into a degenerated tendon or ligament insertion onto the bone (called an enthesis), or into an arthritic joint such as the knee or shoulder.  Like all other forms of regenerative injection therapies, the ultimate goal of prolotherapy is to strengthen and regenerate damaged and painful tissues. 
The origin of Prolotherapy can be traced as far back as the early 1930’s when Dr. Gedney, an osteopathic surgeon, treated his thumb injury with an irritant solution to heal the injured ligaments.  At this time, he termed the injection ‘sclerotherapy.’  Further research was conducted in the mid-1950’s by Dr. Hackett, who later coined the term ‘prolotherapy,’ short for ‘proliferative therapy.’  Dr. Hackett was one of the first physicians to use dextrose as the irritant solution and is regarded as one of the top pioneers in the field of prolotherapy. 


How Prolotherapy Injections Work

Prolotherapy works by stimulating your body’s natural regenerative processes to restore tissue strength and joint stability.  Injected dextrose initiates a temporary, local, and low-grade inflammation that activates fibroblasts in the area as well as triggers the release of different growth factors that help the fibroblasts to perform their function.  When activated, these fibroblasts synthesize new collagen and strengthen the connective tissue in that area.  The result of this natural cascade of events is stronger connective tissue, which helps restore stability to the joint while simultaneously reducing pain.  Prolotherapy has very few adverse side effects and is, therefore, a safer alternative to corticosteroid injections and surgery.



What are the risks and side effects?
Because prolotherapy uses your body’s natural properties to treat your injury, side effects are very uncommon, however, can occur. Some patients have soreness and increased pain for 24-72 hours post-injection. However, this is a normal part of the healing process.
Am I guaranteed results?
Like all medical procedures, regenerative injection procedures have a success and failure rate. An initial consultation with Dr. Timmermans will determine if you are a good candidate. If you are deemed to be a good candidate, our success rate is between 80-90% after a series of treatments.
How many treatments will I need?
While each person and condition are different, the majority of patients require 3-6 injections for the full resolution of pain, spread out every 4-6 weeks. The average number of treatments for complete resolution is 4.
How soon can I return to activity?
After the procedure, we recommend minimal activity for the first 3-7 days, followed by light activity for another seven days, followed by increasing intensity on a weekly basis for another 2-4 weeks. You should be back to full activity within 4-6 weeks. Other therapies offered by Regenerative Performance, such as oral or intravenous supplementation can speed the healing process.
What is the cost?
Because the procedure protocol will vary from person to person and because each person will have a unique condition to be treated, the pricing of procedures can vary considerably from patient to patient. An evaluation will give you a better idea of condition, treatment, and costs specific to your situation.
Does insurance cover this procedure?
Along with other regenerative injection therapies, prolotherapy is not covered by insurance.
How can I prepare for the injection?
We recommend no corticosteroids (inhaled, topical, oral or injection) or blood thinners (e.g. Aspirin) for 4-6 weeks before the procedure and no anti-inflammatory medications (Ibuprofen, Advil, etc.) for one week before the procedure.
How do I get started?
You can get started by booking an appointment with Dr. Timmermans by calling (520) 800-4355.


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